Why are enteric coated or film coated tablets not appropriate to be crushed for administration via enteral feeding?

Why are enteric coated or film coated tablets not appropriate to be crushed for administration via enteral feeding?

• A. They are difficult to crush
• B. They do not crush well and tend to clump and increase the risk of clogging the tube
• C. They are absorbed poorly when crushed
• D. They taste bad

Answer: (B)

Enteric-coated and film-coated tablets are designed with a protective coating to delay release until the drug reaches the small intestine and to shield the stomach from irritation. Crushing these tablets breaks that coating, which can lead to unpredictable release and potential irritation, and in the setting of enteral feeding, the powdered coating and drug particles tend to clump and form particulates that can clog and obstruct the feeding tube. Because tube occlusion is a major safety and dosing issue, these formulations should not be crushed for enteral administration. If a patient needs tube feeding, look for a non-coated, liquid, or alternative formulation and follow pharmacist guidance.

Enteric-coated and film-coated tablets are designed with a protective coating to delay release until the drug reaches the small intestine and to shield the stomach from irritation. Crushing these tablets breaks that coating, which can lead to unpredictable release and potential irritation, and in the setting of enteral feeding, the powdered coating and drug particles tend to clump and form particulates that can clog and obstruct the feeding tube. Because tube occlusion is a major safety and dosing issue, these formulations should not be crushed for enteral administration. If a patient needs tube feeding, look for a non-coated, liquid, or alternative formulation and follow pharmacist guidance.