List the four nutrient disorders frequently associated with cyclosporine use after solid organ transplant.

List the four nutrient disorders frequently associated with cyclosporine use after solid organ transplant.

• A. Hyperkalemia; Hypomagnesemia; Hyperglycemia; Hypercholesterolemia
• B. Hyperkalemia; Hypomagnesemia; Hypoglycemia; Hypercholesterolemia
• C. Hyperkalemia; Hypermagnesemia; Hyperglycemia; Hypocholesterolemia
• D. Hyperkalemia; Hypomagnesemia; Hyperglycemia; Hypocholesterolemia

Answer: (A)

Cyclosporine commonly causes disturbances in electrolytes, glucose, and lipids after solid organ transplantation. Hyperkalemia occurs due to cyclosporine-related nephrotoxicity and reduced renal potassium excretion. Hypomagnesemia results from renal Mg wasting induced by the drug. Hyperglycemia can develop from insulin resistance and impaired pancreatic beta-cell function with cyclosporine. Hypercholesterolemia is also seen, as cyclosporine can alter hepatic lipid metabolism and raise cholesterol levels. Other patterns listed, like hypermagnesemia or hypocholesterolemia or hypoglycemia, don’t fit with cyclosporine’s typical effects, since the drug tends to lower magnesium, raise lipids, and raise glucose rather than vice versa.

Cyclosporine commonly causes disturbances in electrolytes, glucose, and lipids after solid organ transplantation. Hyperkalemia occurs due to cyclosporine-related nephrotoxicity and reduced renal potassium excretion. Hypomagnesemia results from renal Mg wasting induced by the drug. Hyperglycemia can develop from insulin resistance and impaired pancreatic beta-cell function with cyclosporine. Hypercholesterolemia is also seen, as cyclosporine can alter hepatic lipid metabolism and raise cholesterol levels.

Other patterns listed, like hypermagnesemia or hypocholesterolemia or hypoglycemia, don’t fit with cyclosporine’s typical effects, since the drug tends to lower magnesium, raise lipids, and raise glucose rather than vice versa.